A collection of essays devoted to the problem of explanation in various disciplines of science and humanities: mathematics, physics, chemistry, biology, neuroscience, economics as well as theology. The issues covered include such topics as the interplay between explanation and understanding, the problem of a priori explanation, the limits of causal explanations in physics, the application of mathematics in biology, the relationship between proof and explanation in mathematics, and the use of mechanistic framework in neuroscience viewed from the perspective of philosophy of science. Moreover, various methodological controversies related to science and humanities are considered. Contributors: Robert Audi, Bartosz Brożek, Willem B. Drees, Michał Furman, Marcin Gorazda, Michael Heller, Mateusz Hohol, Andrzej Koleżyński, Stanisław Krajewski, Dominique Lambert, Olivier Riaudel, Jan Woleński, Krzysztof Wójtowicz, Wojciech Załuski.